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Ofloxacin (Floxin)

Category:

  • Antibiotic

Description:

  • Fluoroquinolone antibiotic

Indications:

  • Lower respiratory tract infections (H. influenzae, S. pneumoniae)

  • Sexually transmitted diseases (N. gonorrhoeae, Chlamydia trachomatis)

  • Skin infections (P. mirabilis, S. pyogenes, S. aureus)

  • Urinary tract infections (Citrobacter diversus, Enterbacter aerogenes, E. coli, K. pneumoniae, P. mirabilis, P. aeruginosa)

  • Prostatitis (E. coli)  

Contraindications:

  • None

Precautions:

  • Pregnancy category C

  • May cause photosensitivity reactions

  • May cause pseudomembranous colitis

  • Do not use in young children due to possible cartilage abnormalities

  • May cause ophthalmologic abnormalities

  • Administer on an empty stomach, DO NOT take with food

  • Do not take with antacids, iron, aluminum, magnesium or zinc preparations, milk or dairy products

  • May cause dizziness or lightheadedness, use caution when performing tasks

  • Take each dose with a full glass of water

  • Complete full course of therapy

  • Not effective against syphilis

  • Administer by IV infusion only over a period of not less than 60 minutes, DO NOT administer by IM, intrathecal, intraperitoneal or SQ

Adverse Reactions (Side Effects):

  • Chest pain (1-3%), cough

  • Bad taste in mouth

  • Nausea (3-10%), anorexia

  • Headache, dizziness, insomnia, restlessness

  • Vaginal discharge, genital pruritis and itching

Dosage:

  • Administered orally (tablets) and by IV injection

  • UTIs: 

    • 200mg po q12h for 3-10 days depending on severity

  • Lower resp joint infection: 

    • 400mg po q12h for 10 days

  • Skin infection: 

    • 400mg po q12h for 10 days

  • Prostatitis: 

    • 300mg po q12h for 6 weeks

  • Epididymitis: 

    • 300mg po q12h for 10 days

  • PID: 

    • 400mg po q12h for 14 days (with clindamycin or metronidazole)

  • STDs:

    • acute, uncomplicated gonorrhea: 400mg single dose

    • cervicitis (C. trachomatis): 300mg q12h for 7 days

    • cervicits/urethritis (C. trachomatis, N. gonorrhoeae): 300mg q12h for 7 days

 

 


The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks

Source: Operational Medicine 2001,  Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300

This information is provided by The Brookside Associates.  The Brookside Associates, LLC. is a private organization, not affiliated with any governmental agency. The opinions presented here are those of the author and do not necessarily represent the opinions of the Brookside Associates or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. All material presented here is unclassified.

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