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Estradiol (Estrase, Estraderm)

Category:

  • Hormonal

Description:

  • Estrogen hormone

Indications:

  • Menopausal vasomotor symptoms (hot flashes, etc.)

  • Female hypogonadism

  • Female castration and primary ovarian failure

  • Atrophic conditions caused by deficient estrogen production

Contraindications:

  • Known or suspected breast cancer

  • Known or suspected estrogen-dependent neoplasia

  • Known or suspected pregnancy

  • Undiagnosed genital bleeding

  • Current or history of thrombophlebitis, thrombosis, thromboembolic disorders (except when used in breast or prostatic cancer treatment).

Precautions:

  • Pregnancy category X

  • Use with caution in patients with hypertension, diabetes, epilepsy, cardiac, liver or renal dysfunction, history of depression, gall bladder disease, hepatic adenoma.

  • Use with caution in nursing mothers.

  • Use with extreme caution in women with a family history of breast cancer or who have breast nodules.

  • Perform periodic breast examinations.

  • Rotate patch application sites to decrease skin sensitivity.

  • May decrease glucose intolerance in diabetic patients.

  • Discontinue therapy and contact health care provider if pregnancy is suspected.

Adverse Reactions (Side Effects):

  • Thromboembolic disorders

  • Abnormal menstrual bleeding, breast tenderness

  • Edema, weight change

  • Depression

  • Application site irritation

Dosage:

  • Administered orally or transdermal patch

  • 1-2gm per day, attempting to achieve lowest possible dose

  • 10-20cm2 per patch applied twice weekly, rotating sites (avoid breasts and waistline)

 


The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks

Source: Operational Medicine 2001,  Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300

This information is provided by The Brookside Associates.  The Brookside Associates, LLC. is a private organization, not affiliated with any governmental agency. The opinions presented here are those of the author and do not necessarily represent the opinions of the Brookside Associates or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. All material presented here is unclassified.

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