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Danazol (Danacrine)

Category:

  • Hormonal

Description:

  • Synthetic androgen

Indications:

  • Endometriosis

  • Fibrocystic breast disease

  • Hereditary angioedema

Contraindications:

  • Pregnancy and lactation

  • Undiagnosed vaginal bleeding

  • Markedly impaired hepatic, renal or cardiac function

Precautions:

  • Pregnancy category X

  • Rule out breast cancer prior to initiating treatment.

  • Begin endometriosis and fibrocystic breast disease therapy after ruling out pregnancy and during menstrual cycle.

  • May cause irreversible androgenic effects (hirsutism, decreased breast size, deepening of voice, clitoral hypertrophy)

Adverse Reactions (Side Effects):

  • Androgenic: acne, oily kin/hair, weight gain, mild hirsutism, decreased breast size, deepening of voice, clitoral hypertrophy, testicular hypotrophy

  • Hypoestrogenic: flushing, sweating, vaginitis, nervousness, emotional disorders

  • Hepatic dysfunction

  • CNS: dizziness, headache, sleep disorders, fatigue

  • Muscle cramps, joint pain and swelling

Dosage:

  • Administered orally

  • Mild Endometriosis: 

    • 200-400mg/day in two divided doses

  • Endometriosis: 

    • 800mg/day in two divided doses

  • Fibrocystic breast disease: 

    • 100-400mg/day in two divided doses

  • Hereditary angioedema: 

    • 200mg 2-3 times a day, decrease dose to individualized therapy

 


The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks

Source: Operational Medicine 2001,  Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300

This information is provided by The Brookside Associates.  The Brookside Associates, LLC. is a private organization, not affiliated with any governmental agency. The opinions presented here are those of the author and do not necessarily represent the opinions of the Brookside Associates or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. All material presented here is unclassified.

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