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Sodium Polystyrene Sulfonate (Kayexalate)

Category:

  • Electrolyte and water

Description:

  • Electrolyte and renal agent

Indications:

  • Hyperkalemia

Contraindications:

  • Hypokalemia

  • Hypocalcemia

Precautions:

  • Pregnancy category A

  • Pregnacy

  • Sodium restriction

Adverse Reactions (Side Effects):

  • anorexia, bowel necrosis, bowel obstruction, constipation, diarrhea

  • hypocalcemia, hypokalemia, nausea, vomiting

  • sodium retention

Dosage:

Administered orally, rectally: Dose individualized depending on the daily assessment of total body potassium

  • Adult: 

    • PO 15g (about 4 teaspoonsful of the powder or 60 ml of the commercially available suspension) 1-4 times daily

  • Child: 

    • PO 1 g/kg every 6 hours as needed

  • Note: Each dose of the powdered resin is usually given PO as a suspension in water or in a syrup such as sorbitol.  The amount of fluid may range 20-100 ml, depending upon the dose, or 3-4 ml per gram of resin.  Suspensions should be freshly prepared and not stored longer than 24 hours.  The powder should not be mixed with liquids that contain large amounts of potassium, such as orange juice.

  • Adult: 

    • PR 30-50 grams as retention enema every 1-2 hours initially as needed and then every 6 hours

  • Child: 

    • PR 1 g/kg every 2-6 hours as required

 


The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks

Source: Operational Medicine 2001,  Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300

This information is provided by The Brookside Associates.  The Brookside Associates, LLC. is a private organization, not affiliated with any governmental agency. The opinions presented here are those of the author and do not necessarily represent the opinions of the Brookside Associates or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. All material presented here is unclassified.

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