page header

Contents  ·  Introduction  ·  Learning  Objectives  ·  Textbook  ·  Lectures  ·  Procedures  ·  Final Exam  ·  Library  ·  Laboratory  ·  Pharmacy  ·  Imaging  ·  Forms  ·  Videos  ·  About  ·  Contact Us>

Mannitol (Osmitrol, Resectisol)

Category:

  • Diuretic

Description:

  • Osmolar diuretic

Indications:

  • Reduction of intracranial pressure associated with cerebral edema

  • Reduction of intraocular pressure

  • Improve renal function in oliguric phase of acute renal failure

  • Promote urinary excretion of toxic substances

Contraindications:

  • Active intracranial bleeding

  • Anuria; severe pulmonary congestion or edema; severe dehydration  

Precautions:

  • Pregnancy category C

  • Monitor serum electrolytes, urine output  

Adverse Reactions (Side Effects):

  • CNS: confusion, dizziness, seizures, headache, rebound increased intracranial pressure

  • CV: angina-like chest pain, CHF, edema, hypertension, hypotension, tachycardia, thrombophlebitis

  • EENT: blurred vision, loss of hearing, nasal congestion

  • GU: osmotic necrosis, urinary retention

  • METAB: acidosis, dehydration, electrolyte loss, fluid and electrolyte imbalances

  • SKIN: skin necrosis, urticaria

  • MISC: chills, fever  

Dosage:

Administered intravenously

  • Adult: Oliguria prevention: 

    • IV 50-100 grams of 5%-25% solution

    • Oliguria treatment: 

      • IV 50-100 grams of 15%-20% solution

    • Intraocular pressure, intracranial pressure: 

      • IV 1.5-2 g/kg of 15%-25% solution over 30-60 minutes

    • Diuresis in drug intoxication: 

      • IV 5%-10% solution continuously up to 200 grams while maintaining urine output of 100-500 ml/hr

    • Urologic irrigation: 

      • Add contents of two 50ml vials of 25% mannitol to 900ml sterile water for injection and use as irrigation

  • Child: 

    • IV 0.5-1 g/kg initially,k then 0.25-0.5 g/kg every 4-6 hours for maintenance

 


The information contained here is an abbreviated summary. For more detailed and complete information, consult the manufacturer's product information sheets or standard textbooks

Source: Operational Medicine 2001,  Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300

This information is provided by The Brookside Associates.  The Brookside Associates, LLC. is a private organization, not affiliated with any governmental agency. The opinions presented here are those of the author and do not necessarily represent the opinions of the Brookside Associates or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. All material presented here is unclassified.

C. 2009, 2014, All Rights Reserved

brookside associates logo

 

 

 

 

 

 

Advertise on this site