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Progesterone

Progesterone is a female hormone, produced primarily in the ovary, primarily during the second half ("luteal phase") of the menstrual cycle. Men also produce progesterone, but only very small amounts.

Shortly after ovulation, progesterone levels rise quickly and remain elevated for about 10 days. 

  • If pregnancy occurs, the progesterone levels remain elevated. 
  • If pregnancy does not occur, then progesterone levels fall, provoking a menstrual flow.

Progesterone levels are sometimes used to evaluate a possible ectopic pregnancy:

  • If progesterone > 25, ectopic pregnancy is very unlikely
  • When less than 25, the results are not conclusive either way.

Elevations found in:

  • Pregnancy
  • Second half of the menstrual cycle
  • Congenital adrenal hyperplasia
  • Some hormone-producing tumors of the ovary

Decreases found in:

  • Polycystic Ovary Syndrome (PCO, Stein-Levinthal Syndrome)
  • Amenorrhea-Galactorrhea Syndrome
  • Luteal phase defects
  • Menopause
  • Ovarian failure

Normal Values*

Men < 1.0 ng/ml

Women 
(Proliferative Phase)

< 1.5 ng/ml
Women
(Luteal Phase)
3-20 ng/ml

*These are general values taken from a variety of sources. The actual normal values may vary from lab to lab and from one type of testing protocol to another.

progesterone levels during one menstrual cycle

Source: Operational Medicine 2001,  Health Care in Military Settings, NAVMED P-5139, May 1, 2001, Bureau of Medicine and Surgery, Department of the Navy, 2300 E Street NW, Washington, D.C., 20372-5300

Military Obstetrics & Gynecology
© 2003, 2004, 2005, 2006 Medical Education Division, Brookside Associates, Ltd.
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This information is provided by The Brookside Associates.  The Brookside Associates, LLC. is a private organization, not affiliated with any governmental agency. The opinions presented here are those of the author and do not necessarily represent the opinions of the Brookside Associates or the Department of Defense. The presence of any advertising on these pages does not constitute an endorsement of that product or service by either the US Department of Defense or the Brookside Associates. All material presented here is unclassified.

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